A research and diagnostic laboratory specialising in Vitamin D biology research in companion, production and wild animals

VitDAL publishes new paper


Posted on March 29th, by Richard Mellanby in Uncategorized. No Comments

VitDAL has published its latest research on the immune-modulating properties of vitamin D. We have explored the effects of the active vitamin D metabolite 1,25(OH)2D3 on bone marrow derived dendritic cells (BMDC) and discovered that CD31 was one of a small number of genes which were over-expressed on both activated and non-activated 1,25(OH)2D3 conditioned BMDC. Using lentivirus transfection systems we over- and under-expressed CD31 on BMDC revealing that CD31 acted as a brake on T cell activation. We showed that the expression of CD31 prevented cells from establishing long lasting interactions with BMDC thereby limiting potential for T cell activation.

The full paper can be accessed via this link





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