VitDAL has published its latest research on the immune-modulating properties of vitamin D. We have explored the effects of the active vitamin D metabolite 1,25(OH)2D3 on bone marrow derived dendritic cells (BMDC) and discovered that CD31 was one of a small number of genes which were over-expressed on both activated and non-activated 1,25(OH)2D3 conditioned BMDC. Using lentivirus transfection systems we over- and under-expressed CD31 on BMDC revealing that CD31 acted as a brake on T cell activation. We showed that the expression of CD31 prevented cells from establishing long lasting interactions with BMDC thereby limiting potential for T cell activation.

The full paper can be accessed via this link