VitDAL publish latest research on canine Vitamin D Receptor

The VitDAL have published their latest paper this week describing vitamin D receptor expression in dogs. Using immunohistochemistry we demonstrated that vitamin D receptor expression was highest in the kidney, duodenum, skin, ileum and spleen. The cells stained brown in the histology image on the left shows vitamin D receptor expression in the duodenum, the tissue which most intensely expressed vitamin D receptors. We also explored how vitamin D receptor expression varied in the presence of inflammation by comparing vitamin D receptor expression in dogs with inflammatory bowel disease and healthy controls. We discovered that vitamin D receptor expression was unchanged in the face of inflammation, a finding which is encouraging us to explore whether vitamin D may be used as an immuno-modulatory therapy in dogs with intestinal inflammation.